Protection Occurs through a Receptor-targeting Modulation Simple Epithelium Keratins 8 and 18 Provide Resistance to Fas-mediated Apoptosis. the Cam Kinase Ii Regulation of Crhsp-28 Phosphorylation in Cultured Mucosal T84 Cells Ajp -gastrointestinal and Liver Physiology
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[PDF] [Full Text] [Abstract] , May 24, 2001; 344 (21): 1580-1587. N. Engl. J. Med. N.-O. Ku, R. Gish, T. L. Wright and M. B. Omary Keratin 8 Mutations in Patients with Cryptogenic Liver Disease [PDF] [Full Text] [Abstract] , August 20, 2001; 154 (4): 763-774. J. Cell Biol. S. Gilbert, A. Loranger, N. Daigle and N. Marceau protection occurs through a receptor-targeting modulation Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The [PDF] [Full Text] [Abstract] , March 9, 2002; 114 (14): 2569-2575. J. Cell Sci. M. Hesse, T. M. Magin and K. Weber 18 keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and Genes for intermediate filament proteins and the draft sequence of the human genome: novel [PDF] [Full Text] [Abstract] , April 2, 2002; 99 (7): 4373-4378. PNAS N.-O. Ku, S. Michie, E. Z. Resurreccion, R. L. Broome and M. B. Omary progression Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic [PDF] [Full Text] [Abstract] , December 1, 2003; 285 (6): G1300-G1309. Am J Physiol Gastrointest Liver Physiol K. M. Kaspar, D. D. H. Thomas, W. B. Taft, E. Takeshita, N. Weng and G. E. Groblewski CaM kinase II regulation of CRHSP-28 phosphorylation in cultured mucosal T84 cells
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CaM kinase II regulation of CRHSP-28 phosphorylation in cultured mucosal T84 cells.
Ca(2+)-regulated heat-stable protein of 28 kDa (CRHSP-28; a member of the tumor protein D52 family) is highly expressed in exocrine glands and was shown to regulate digestive enzyme secretion from pancreatic acinar cells. We found CRHSP-28 highly expressed in cultured mucosal secretory T84 cells, consistent with an important regulatory role in apical membrane trafficking. Stimulation of cells w...
متن کاملSimple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation
Keratins 8 and 18 belong to the keratin family of intermediate filament (IF) proteins and constitute a hallmark for all simple epithelia, including the liver. Hepatocyte IFs are made solely of keratins 8 and 18 (K8/K18). In these cells, the loss of one partner via a targeted null mutation in the germline results in hepatocytes lacking K8/K18 IFs, thus providing a model of choice for examining t...
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Intermediate filament proteins (IFs), such as cytoplasmic keratins in epithelial cells and vimentin in mesenchymal cells and the nuclear lamins, make up one of the three major cytoskeletal protein families. Whether in digestive organs or other tissues, IFs share several unique features including stress-inducible overexpression, abundance, cell-selective and differentiation state expression, and...
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Interleukin-11 (IL-11) displays epithelial cytoprotective effects during intestinal injury. Antiapoptotic effects of IL-11 have been described, yet mechanisms remain unclear. Fas/CD95 death receptor signaling is upregulated in ulcerative colitis, leading to mucosal breakdown. We hypothesized that IL-11 inhibits Fas ligand (FasL)-mediated apoptosis in intestinal epithelia. Cell death was monitor...
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